There are few things more frustrating than hitting reply and composing an email only to realize that you’re replying to DONOTREPLY@wedontcareaboutyou.com.
I think using a DO NOT REPLY address is one of rudest things a company can do. ¬†It’s tantamount to saying “We don’t care if you want to talk to us.”
Just my 2 cents…take it or leave it.
Jon Dale 
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Just seeing “Do Not Reply” is a turnoff. ¬†It’s a negative statement.